Have my receptors stopped responding?

Answer

The maintenance trials do not support that. When treatment continued, loss continued; when it was swapped for placebo, weight came back.

In more detail

In STEP 4, people who continued semaglutide 2.4 mg from week 20 to week 68 lost a further 7.9%, while those switched to placebo regained 6.9%. SURMOUNT-4 found the same shape on tirzepatide: continuing produced an additional 5.5% by week 88, while the placebo-switched group regained about 14%. If the receptors had desensitised, the continuing arms would have drifted back up alongside the placebo ones. They did not.

Source

Rubino 2021 (PMID 33755728); Aronne 2024 (PMID 38078870).

Educational use only, never medical advice. No doses.