Vardenafil

Status

FDA-approved. Approved as Levitra and Staxyn for erectile dysfunction. Contraindicated with nitrates in any form — the combination can cause a catastrophic drop in blood pressure. Caution with alpha-blockers.

What it is

A PDE5 inhibitor for erectile dysfunction, between sildenafil and tadalafil in duration.

What published research measured

A phosphodiesterase type 5 inhibitor with a similar duration to sildenafil and greater in vitro potency, though that potency does not translate into a clinically meaningful difference at approved amounts. Randomized trial evidence for erectile dysfunction is substantial. It prolongs the QT interval slightly more than the others in its class, which matters for anyone on other QT-prolonging medicines.

Source

Hatzimouratidis K et al. 2010 — Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation · Bender AT et al. 2006 — Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use · Serafini P et al. 2006 — Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell fun…

Sources

• Half-life source for Vardenafil