PEG-MGF
Status
No approved product. No FDA-approved labeling exists, and no approval elsewhere is listed in this site's sources. Not an FDA-approved medicine; where sold as a research-use-only chemical, the FDA has not reviewed its identity, purity or content before sale.
What it is
A pegylated mechano growth factor variant studied in muscle models.
What published research measured
The same 24-amino-acid mechano growth factor E-peptide as the unmodified entry in this library, with a polyethylene glycol chain attached to slow clearance. The honest state of the evidence is thinner than for almost anything else catalogued here: this entry does not cite any published human therapeutic trial of PEG-MGF, or any peer-reviewed pharmacokinetic study measuring its half-life in humans or in animals. The half-life figure quoted for this compound across the internet, and shown in the specification strip above, is not a measured value — it appears to be extrapolated from full-length pegylated recombinant IGF-1, a substantially different and larger molecule. Treat it as unverified. Everything inferred about what the peptide does rests on the unmodified MGF literature, which is itself contested and includes a failed independent replication. One risk specific to the pegylated form is rarely discussed in community write-ups: anti-PEG antibodies can develop on repeat exposure to pegylated drugs, which is a recognized problem across that whole drug class and has no reason to spare this one. Prohibited at all times in sport under WADA class S2.
Source
Yang et al. 1996, original cloning of the IGF-1Ec splice variant · Fornaro et al. 2013, American Journal of Physiology: Endocrinology and Metabolism — replication failure for the unmodified E peptide · Frontiers in Endocrinology 2026 review — performance-enhancing peptides modulating the GH–IGF-1 axis, covering PEG-MGF and IGF-1 LR3 · Anti-PEG antibody literature on repeat exposure to pegylated therapeutics · WADA Prohibited List, class S2
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.