PDRN
Status
Approved elsewhere. No FDA-approved labeling exists in the United States, where PDRN products are neither approved as drugs nor cleared as devices. It is a registered medicine in Italy and is approved in South Korea and several other countries.
What it is
A salmon DNA-derived preparation used in aesthetic skin treatments.
What published research measured
Polydeoxyribonucleotide, a mixture of DNA fragments purified from salmon or trout gonadal tissue, which acts principally as an adenosine A2A receptor agonist and additionally supplies nucleotides through the salvage pathway. It has a more substantial clinical record than most of this category and is a registered medicine in Italy and widely used in Korea: randomized and controlled studies report benefit in diabetic foot ulcers and other chronic wounds, in tissue repair after surgery, and in osteoarthritis when injected intra-articularly. Aesthetic use by intradermal injection for skin quality is popular and less well evidenced than the wound-healing indications, resting largely on open-label and small comparative studies. Because it is derived from fish tissue, it is inappropriate for anyone with a relevant allergy.
Source
Randomized and controlled studies of PDRN in diabetic foot ulcers and osteoarthritis
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.