Oxytocin Troche
Status
No approved product. No FDA-approved labeling exists for buccal or sublingual oxytocin. Troches are compounded preparations, which are not reviewed by the FDA for safety, efficacy or absorption.
What it is
A dissolving lozenge form of oxytocin used in some clinics.
What published research measured
Oxytocin formulated as a lozenge dissolved in the mouth, intended to allow absorption across the buccal mucosa and avoid the gut. The pharmacological question this route raises is not adequately answered in published work: oxytocin is a peptide of nine amino acids and its buccal bioavailability in humans has not been well characterized, so the exposure achieved from a troche is uncertain in a way that injectable oxytocin's is not. The clinical claims made for it in sexual and relational contexts rest on the intranasal social-neuroscience literature, which is itself contested and marked by replication failures, and no randomized trial has tested a buccal oxytocin product for those indications.
Source
Not tied to a single designated source; see the published research on this molecule
Sources
No linked primary source is on file for this entry yet.
Educational use only, never medical advice. No doses.