Klotho

Status

No approved product. No approved product found in the regulators this site checks. Klotho is an endogenous protein studied as a biomarker and, in animals, as an administered research preparation.

What it is

A protein the body makes, studied in ageing and cognition. Research covers the full protein, individual domains such as KL1, and circulating levels — which are not one interchangeable injectable 'peptide'.

What published research measured

A 2023 experiment gave aged rhesus macaques a single subcutaneous research exposure of rhesus klotho and measured a spatial memory task; the benefit was seen at the lower exposure, not the higher one. In people, a published 16-woman topical pilot of a klotho-protein skin serum (PubMed 40911741) reported investigator-rated improvement in fine lines and wrinkles from baseline over 12 weeks; it was small, measured cosmetic skin outcomes and cannot establish systemic or injectable efficacy. No results are posted for the three listed systemic gene/mRNA registry trials, and no human study establishes an injectable amount, frequency or duration.

Source

Castner SA et al. 2023, Nature Aging — klotho and cognition in aged rhesus macaques · PubMed 40911741 (J Drugs Dermatol 2025) — topical klotho-protein serum pilot, 16 women Primary source

Sources

• Castner SA et al. 2023, Nature Aging — klotho and cognition in aged rhesus macaques · PubMed 40911741 (J Drugs Dermatol 2025) — topical klotho-protein serum pilot, 16 women
• PubMed 40911741 (topical skin serum pilot, 16 women, baseline comparison)
• Urakawa et al. 2006, Nature: klotho and the FGF23 receptor (PubMed 17086194)
• PubMed 37587231 (platelet factor, mice)
• NCT07216781
• NCT07285629
• NCT07544420
• Primary source
• CDC handling principles