Ca-AKG

Also known as: calcium alpha-ketoglutarate, AKG

Status

Dietary supplement (US). Sold as a dietary supplement. Not approved as a medicine.

What it is

Calcium alpha-ketoglutarate, a Krebs cycle intermediate taken for its animal longevity data.

What published research measured

Alpha-ketoglutarate is a central Krebs cycle intermediate whose blood levels fall substantially with age. Mouse work reported compressed morbidity — less time spent frail at the end of life — more convincingly than extended maximum lifespan, which is a distinction worth keeping. Human data is limited to small open-label work reporting changes in epigenetic age markers, a surrogate measure rather than an outcome.

Source

Not tied to a single designated source; see the published research on this molecule

Sources

No linked primary source is on file for this entry yet.

Educational use only, never medical advice. No doses.